Version 5.4
Homo sapiens Gene: SEC23IP
Summary
InnateDB Gene IDBG-91289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC23IP
Gene Name SEC23 interacting protein
Synonyms P125; P125A
Species Homo sapiens
Ensembl Gene ENSG00000107651
Encoded Proteins
IDBP-91291
SEC23 interacting protein
IDBP-386091
SEC23 interacting protein
IDBP-386092
SEC23 interacting protein
IDBP-586226
SEC23 interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:119892711-119944658
Strand Forward strand
Band q26.11
Transcripts
ENST00000369075 ENSP00000358071
ENST00000442952 ENSP00000416723
ENST00000446561 ENSP00000396906
ENST00000470478
ENST00000462222
ENST00000475542
ENST00000483890
ENST00000543134 ENSP00000438773
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001675 acrosome assembly
GO:0006886 intracellular protein transport
GO:0007030 Golgi organization
GO:0007286 spermatid development
GO:0007338 single fertilization
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005801 cis-Golgi network
GO:0012507 ER to Golgi transport vesicle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0070971 endoplasmic reticulum exit site
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055319
View Gene Order
ENSBTAG00000007441
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.435004 Hs.603565
RefSeq NM_007190 XM_005269469 XM_005269470
HUGO
OMIM
CCDS CCDS7618
HPRD 07152
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca