InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEC23IP

Summary

InnateDB Protein

IDBP-91291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC23IP

Protein Name

SEC23 interacting protein

Synonyms

P125; P125A;

Species

Homo sapiens

Ensembl Protein

ENSP00000358071

InnateDB Gene

IDBG-91289 (SEC23IP)

Protein Structure

UniProt Annotation

Function

Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269PubMed:10400679, ECO:0000269PubMed:15623529, ECO:0000269PubMed:22922100}.

Subcellular Localization

Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle. {ECO:0000269PubMed:10400679}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001675	acrosome assembly
GO:0006886	intracellular protein transport
GO:0007030	Golgi organization
GO:0007286	spermatid development
GO:0007338	single fertilization

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005801	cis-Golgi network
GO:0012507	ER to Golgi transport vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070971	endoplasmic reticulum exit site
GO:0097038	perinuclear endoplasmic reticulum