Version 5.4
Homo sapiens Gene: VAV2
Summary
InnateDB Gene IDBG-91583.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAV2
Gene Name vav 2 guanine nucleotide exchange factor
Synonyms VAV-2
Species Homo sapiens
Ensembl Gene ENSG00000160293
Encoded Proteins
IDBP-91585
vav 2 guanine nucleotide exchange factor
IDBP-91587
vav 2 guanine nucleotide exchange factor
IDBP-294151
vav 2 guanine nucleotide exchange factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:133761894-133992604
Strand Reverse strand
Band q34.2
Transcripts
ENST00000371851 ENSP00000360917
ENST00000371850 ENSP00000360916
ENST00000406606 ENSP00000385362
ENST00000486113
ENST00000472905
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 78 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0010468 regulation of gene expression
GO:0016477 cell migration
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009621
View Gene Order
ENSBTAG00000004511
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_12529
Signaling by VEGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
rac1_reg_pathway
Regulation of RAC1 activity
erbb1_downstream_pathway
ErbB1 downstream signaling
nectin_pathway
Nectin adhesion pathway
epopathway
EPO signaling pathway
rhoa_reg_pathway
Regulation of RhoA activity
bcr_5pathway
BCR signaling pathway
cdc42_pathway
CDC42 signaling events
cdc42_reg_pathway
Regulation of CDC42 activity
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt P52735
TrEMBL
UniProt Splice Variant
Entrez Gene 7410
UniGene Hs.369921
RefSeq XM_005272213 NM_001134398 NM_003371
HUGO HGNC:12658
OMIM 600428
CCDS CCDS48053 CCDS6979
HPRD 02694
IMGT
EMBL AL357934 AL445931 AL590710 AY563001 BC033187 BC132965 BC132967 BX640754 CH471090 S76992
GenPept AAB34377 AAH33187 AAI32966 AAI32968 AAS75591 CAE45861 CAI12278 CAI12279 CAI12280 CAI13722 CAI13723 CAI13724 CAI15781 CAI15782 CAI15783 EAW88108
RNA Seq Atlas 7410

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca