Version 5.4
Mus musculus Gene: Vav2
Summary
InnateDB Gene IDBG-151026.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vav2
Gene Name vav 2 oncogene
Synonyms 2810040F13Rik; AI847175
Species Mus musculus
Ensembl Gene ENSMUSG00000009621
Encoded Proteins
IDBP-151032
vav 2 oncogene
IDBP-788790
vav 2 oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160293:
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27262104-27427033
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000056176 ENSMUSP00000062782
ENSMUST00000149758
ENSMUST00000148067
ENSMUST00000135584
ENSMUST00000146843
ENSMUST00000132642
ENSMUST00000185188 ENSMUSP00000138964
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0007264 small GTPase mediated signal transduction
GO:0010468 regulation of gene expression
GO:0016477 cell migration
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0030193 regulation of blood coagulation
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160293
View Gene Order
ENSBTAG00000004511
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_227951
Signaling by VEGF pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_243590
EPH-ephrin mediated repulsion of cells pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_188202
FCERI mediated Ca+2 mobilization pathway
REACT_210090
Rho GTPase cycle pathway
REACT_215461
Signal transduction by L1 pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_219680
L1CAM interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_188530
FCERI mediated MAPK activation pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04660
T cell receptor signaling pathway pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu04662
B cell receptor signaling pathway pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_12529
Signaling by VEGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
rac1_reg_pathway
Regulation of RAC1 activity
erbb1_downstream_pathway
ErbB1 downstream signaling
nectin_pathway
Nectin adhesion pathway
epopathway
EPO signaling pathway
rhoa_reg_pathway
Regulation of RhoA activity
bcr_5pathway
BCR signaling pathway
cdc42_pathway
CDC42 signaling events
cdc42_reg_pathway
Regulation of CDC42 activity
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.179011 Mm.487557
RefSeq NM_009500 XM_006497854 XM_006497855 XM_006497856
OMIM
CCDS CCDS15827
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca