Version 5.4
Homo sapiens Gene: PRIM2
Summary
InnateDB Gene IDBG-91619.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRIM2
Gene Name primase, DNA, polypeptide 2 (58kDa)
Synonyms p58; PRIM2A
Species Homo sapiens
Ensembl Gene ENSG00000146143
Encoded Proteins
IDBP-811285
primase, DNA, polypeptide 2 (58kDa)
IDBP-811287
primase, DNA, polypeptide 2 (58kDa)
IDBP-811297
primase, DNA, polypeptide 2 (58kDa)
IDBP-811295
primase, DNA, polypeptide 2 (58kDa)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:57314805-57646849
Strand Forward strand
Band p11.2
Transcripts
ENST00000370687 ENSP00000483201
ENST00000274891 ENSP00000485304
ENST00000419977
ENST00000490313
ENST00000470638
ENST00000550475 ENSP00000485395
ENST00000615550 ENSP00000484105
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 21 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003896 DNA primase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006269 DNA replication, synthesis of RNA primer
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0032201 telomere maintenance via semi-conservative replication
Cellular Component
GO:0005654 nucleoplasm
GO:1990077 primosome complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_7987
Polymerase switching on the C-strand of the telomere pathway
REACT_7993
Telomere C-strand synthesis initiation pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_2244
DNA replication initiation pathway
REACT_70
Removal of the Flap Intermediate pathway
REACT_1385
Processive synthesis on the lagging strand pathway
REACT_1792
Polymerase switching pathway
REACT_1838
Leading Strand Synthesis pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_329
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_7970
Telomere Maintenance pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa00230
Purine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P49643
TrEMBL A0A024RD43 H9XFA6 H9XFA7 I0CMJ8
UniProt Splice Variant
Entrez Gene 5558
UniGene Hs.654580 Hs.682700
RefSeq NM_000947 NM_001282487 NM_001282488
HUGO HGNC:9370
OMIM 176636
CCDS CCDS75476 CCDS75477
HPRD
IMGT
EMBL AL121975 AL162579 BC017833 BC064931 CH471081 JQ511937 JQ511938 JQ582410 X74331
GenPept AAH17833 AAH64931 AFG72972 AFG72973 AFH78579 CAA52378 CAH73686 CAI20534 EAX04481 EAX04483
RNA Seq Atlas 5558

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca