Version 5.4
Homo sapiens Protein: PRIM2
Summary
InnateDB Protein IDBP-811295.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRIM2
Protein Name primase, DNA, polypeptide 2 (58kDa)
Synonyms p58; PRIM2A;
Species Homo sapiens
Ensembl Protein ENSP00000484105
InnateDB Gene IDBG-91619 (PRIM2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 21 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003896 DNA primase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006269 DNA replication, synthesis of RNA primer
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0032201 telomere maintenance via semi-conservative replication
Cellular Component
GO:0005654 nucleoplasm
GO:1990077 primosome complex
Protein Structure and Domains
PDB ID
InterPro IPR007238 DNA primase large subunit, eukaryotic/archaeal
IPR016558 DNA primase, large subunit, eukaryotic
PFAM PF04104
PRINTS
PIRSF PIRSF009449
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49643
PhosphoSite PhosphoSite-P49643
TrEMBL I0CMJ8
UniProt Splice Variant
Entrez Gene 5558
UniGene
RefSeq NP_000938
HUGO HGNC:9370
OMIM 176636
CCDS CCDS75476
HPRD
IMGT
EMBL AL121975 AL162579 BC017833 BC064931 JQ511937 JQ511938 JQ582410 X74331
GenPept AAH17833 AAH64931 AFG72972 AFG72973 AFH78579 CAA52378 CAH73686 CAI20534

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca