Version 5.4
Homo sapiens Gene: MFAP2
Summary
InnateDB Gene IDBG-91635.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFAP2
Gene Name microfibrillar-associated protein 2
Synonyms MAGP; MAGP-1; MAGP1
Species Homo sapiens
Ensembl Gene ENSG00000117122
Encoded Proteins
IDBP-91637
microfibrillar-associated protein 2
IDBP-91639
microfibrillar-associated protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:16974502-16980835
Strand Reverse strand
Band p36.13
Transcripts
ENST00000375535 ENSP00000364685
ENST00000375534 ENSP00000364684
ENST00000490075
ENST00000476788
ENST00000478684
ENST00000492598
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0070051 fibrinogen binding
Biological Process
GO:0030198 extracellular matrix organization
GO:0030220 platelet formation
Cellular Component
GO:0001527 microfibril
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060572
View Gene Order
ENSBTAG00000003832
Not yet available
Pathways
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.389137 Hs.618727 Hs.712974
RefSeq NM_001135247 NM_001135248 NM_002403 NM_017459
HUGO
OMIM
CCDS CCDS174 CCDS44071
HPRD 01137
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca