InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTP4A1

Summary

InnateDB Gene

IDBG-91692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTP4A1

Gene Name

protein tyrosine phosphatase type IVA, member 1

Synonyms

HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1

Species

Homo sapiens

Ensembl Gene

ENSG00000112245

Encoded Proteins

IDBP-91694

protein tyrosine phosphatase type IVA, member 1

IDBP-719266

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. [provided by RefSeq, Jul 2008]
This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:63521761-63583587

Strand

Forward strand

Band

q12

Transcripts

ENST00000370651	ENSP00000359685
ENST00000470661
ENST00000473334
ENST00000578299	ENSP00000462406

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	12 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0016311	dephosphorylation
GO:0030335	positive regulation of cell migration
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005819	spindle
GO:0009898	cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026064

View Gene Order

ENSBTAG00000002275

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

prlsignalingeventspathway

Signaling events mediated by PRL

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.227777 Hs.593184 Hs.607235 Hs.706610

RefSeq

NM_003463 XM_006715563

HUGO

OMIM

CCDS

CCDS4965

HPRD

03349

IMGT

EMBL

GenPept

RNA Seq Atlas