InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTP4A1

Summary

InnateDB Protein

IDBP-91694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTP4A1

Protein Name

protein tyrosine phosphatase type IVA, member 1

Synonyms

HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000359685

InnateDB Gene

IDBG-91692 (PTP4A1)

Protein Structure

UniProt Annotation

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. {ECO:0000269PubMed:12235145, ECO:0000269PubMed:12782572, ECO:0000269PubMed:14643450}.

Subcellular Localization

Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle.

Disease Associations

Tissue Specificity

Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines. {ECO:0000269PubMed:10940933, ECO:0000269PubMed:12235145}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	12 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0016311	dephosphorylation
GO:0030335	positive regulation of cell migration
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005819	spindle
GO:0009898	cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt