Version 5.4
Homo sapiens Gene: TOB2
Summary
InnateDB Gene IDBG-9172.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOB2
Gene Name transducer of ERBB2, 2
Synonyms TOB4; TOBL; TROB2
Species Homo sapiens
Ensembl Gene ENSG00000183864
Encoded Proteins
IDBP-9174
transducer of ERBB2, 2
IDBP-378061
transducer of ERBB2, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:41433492-41447023
Strand Reverse strand
Band q13.2
Transcripts
ENST00000327492 ENSP00000331305
ENST00000434408 ENSP00000388549
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042809 vitamin D receptor binding
Biological Process
GO:0007292 female gamete generation
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0045671 negative regulation of osteoclast differentiation
GO:0045778 positive regulation of ossification
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048546
View Gene Order
ENSBTAG00000015109
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt Q14106
TrEMBL B0QXZ4
UniProt Splice Variant
Entrez Gene 10766
UniGene Hs.474978 Hs.600710 Hs.743845
RefSeq NM_016272 XM_005261315 XM_006724105
HUGO HGNC:11980
OMIM 607396
CCDS CCDS14015
HPRD
IMGT
EMBL AB035207 AB051450 AL008582 BC038957 CR456594 CR541684 D64109
GenPept AAH38957 BAA10971 BAA87042 BAB33333 CAB62938 CAG30480 CAG46485
RNA Seq Atlas 10766

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca