Version 5.4
Homo sapiens Protein: TOB2
Summary
InnateDB Protein IDBP-9174.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOB2
Protein Name transducer of ERBB2, 2
Synonyms TOB4; TOBL; TROB2;
Species Homo sapiens
Ensembl Protein ENSP00000331305
InnateDB Gene IDBG-9172 (TOB2)
Protein Structure
UniProt Annotation
Function Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042809 vitamin D receptor binding
Biological Process
GO:0007292 female gamete generation
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0045671 negative regulation of osteoclast differentiation
GO:0045778 positive regulation of ossification
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002087 Anti-proliferative protein
IPR009818 Ataxin-2, C-terminal
PFAM PF07742
PF07145
PRINTS PR00310
PIRSF
SMART SM00099
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14106
PhosphoSite PhosphoSite-Q14106
TrEMBL B0QXZ4
UniProt Splice Variant
Entrez Gene 10766
UniGene Hs.743845
RefSeq NP_057356
HUGO HGNC:11980
OMIM 607396
CCDS CCDS14015
HPRD 09583
IMGT
EMBL AB035207 AB051450 AL008582 BC038957 CR456594 CR541684 D64109
GenPept AAH38957 BAA10971 BAA87042 BAB33333 CAB62938 CAG30480 CAG46485

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca