Version 5.4
| Homo sapiens Gene: LCN1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-91995.7 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | LCN1 | ||||||||||||||||||
| Gene Name | lipocalin 1 | ||||||||||||||||||
| Synonyms | PMFA; TLC; TP; VEGP | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000160349 | ||||||||||||||||||
| Encoded Proteins |
lipocalin 1 (tear prealbumin)
lipocalin 1 (tear prealbumin)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011] This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren\'s syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 9:135521438-135526532 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q34.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Transport of fatty acids pathway
Transport of vitamins, nucleosides, and related molecules pathway
Transmembrane transport of small molecules pathway
Orphan transporters pathway
SLC-mediated transmembrane transport pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P31025 | ||||||||||||||||||
| TrEMBL | A0A024R8D7 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 3933 | ||||||||||||||||||
| UniGene | Hs.530311 | ||||||||||||||||||
| RefSeq | NM_001252617 NM_001252618 NM_001252619 NM_002297 | ||||||||||||||||||
| HUGO | HGNC:6525 | ||||||||||||||||||
| OMIM | 151675 | ||||||||||||||||||
| CCDS | CCDS6991 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AL161452 BC065721 BC074925 BC074926 CH471090 L14927 M90424 X62418 X67647 | ||||||||||||||||||
| GenPept | AAA18633 AAA61845 AAH65721 AAH74925 AAH74926 CAA44284 CAA47889 CAI14045 EAW88156 EAW88157 | ||||||||||||||||||
| RNA Seq Atlas | 3933 | ||||||||||||||||||