InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LCN1

Summary

InnateDB Protein

IDBP-91997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LCN1

Protein Name

lipocalin 1 (tear prealbumin)

Synonyms

PMFA; TLC; TP; VEGP;

Species

Homo sapiens

Ensembl Protein

ENSP00000263598

InnateDB Gene

IDBG-91995 (LCN1)

Protein Structure

UniProt Annotation

Function

Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Mainly expressed in lachrymal and salivary glands. Also expressed in the prostate.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity

Biological Process

GO:0001895	retina homeostasis
GO:0006508	proteolysis
GO:0006810	transport
GO:0010951	negative regulation of endopeptidase activity
GO:0050896	response to stimulus
GO:0050909	sensory perception of taste