Version 5.4
Homo sapiens Gene: MPP1
Summary
InnateDB Gene IDBG-92097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPP1
Gene Name membrane protein, palmitoylated 1, 55kDa
Synonyms AAG12; DXS552E; EMP55; MRG1; PEMP
Species Homo sapiens
Ensembl Gene ENSG00000130830
Encoded Proteins
IDBP-92099
membrane protein, palmitoylated 1, 55kDa
IDBP-92101
membrane protein, palmitoylated 1, 55kDa
IDBP-243439
membrane protein, palmitoylated 1, 55kDa
IDBP-243441
membrane protein, palmitoylated 1, 55kDa
IDBP-383919
membrane protein, palmitoylated 1, 55kDa
IDBP-383920
membrane protein, palmitoylated 1, 55kDa
IDBP-383924
membrane protein, palmitoylated 1, 55kDa
IDBP-383927
membrane protein, palmitoylated 1, 55kDa
IDBP-383929
membrane protein, palmitoylated 1, 55kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:154778684-154821007
Strand Reverse strand
Band q28
Transcripts
ENST00000369534 ENSP00000358547
ENST00000369531 ENSP00000358544
ENST00000393531 ENSP00000377165
ENST00000393529 ENSP00000377163
ENST00000413259 ENSP00000400155
ENST00000439370 ENSP00000400700
ENST00000453245 ENSP00000410888
ENST00000428488 ENSP00000391701
ENST00000417435 ENSP00000389321
ENST00000491955
ENST00000482757
ENST00000494170
ENST00000462825
ENST00000493871
ENST00000475943
ENST00000488754
ENST00000488694
ENST00000471821
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004385 guanylate kinase activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0046939 nucleotide phosphorylation
GO:0090022 regulation of neutrophil chemotaxis
Cellular Component
GO:0005622 intracellular
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0032420 stereocilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031402
View Gene Order
ENSBTAG00000013046
Not yet available
Cross-References
SwissProt Q00013
TrEMBL A6NFY0 A8MTH1 C9J9J4 C9JB34 F8WC84 F8WDV6
UniProt Splice Variant
Entrez Gene 4354
UniGene Hs.496984
RefSeq NM_001166460 NM_001166461 NM_001166462 NM_002436
HUGO HGNC:7219
OMIM 305360
CCDS CCDS14762 CCDS55544 CCDS55545
HPRD
IMGT
EMBL AC109993 AK290246 AK303111 AK312296 AK315957 AY423731 AY634686 BC002392 CH471172 M64925 M87059 U39611
GenPept AAA60059 AAA60060 AAD14835 AAH02392 AAS00494 AAV35469 BAF82935 BAG35223 BAG64217 BAH14328 EAW72655 EAW72656 EAW72660
RNA Seq Atlas 4354

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca