Version 5.4
Homo sapiens Gene: KCNQ5
Summary
InnateDB Gene IDBG-92219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNQ5
Gene Name potassium voltage-gated channel, KQT-like subfamily, member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185760
Encoded Proteins
IDBP-92221
potassium voltage-gated channel, KQT-like subfamily, member 5
IDBP-92223
potassium voltage-gated channel, KQT-like subfamily, member 5
IDBP-92225
potassium voltage-gated channel, KQT-like subfamily, member 5
IDBP-92227
potassium voltage-gated channel, KQT-like subfamily, member 5
IDBP-92229
potassium voltage-gated channel, KQT-like subfamily, member 5
IDBP-294167
potassium voltage-gated channel, KQT-like subfamily, member 5
IDBP-294171
potassium voltage-gated channel, KQT-like subfamily, member 5
IDBP-383170
potassium voltage-gated channel, KQT-like subfamily, member 5
IDBP-383171
potassium voltage-gated channel, KQT-like subfamily, member 5
IDBP-383173
potassium voltage-gated channel, KQT-like subfamily, member 5
IDBP-383174
potassium voltage-gated channel, KQT-like subfamily, member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:72621792-73198851
Strand Forward strand
Band q13
Transcripts
ENST00000370398 ENSP00000359425
ENST00000370392 ENSP00000359419
ENST00000355635 ENSP00000347853
ENST00000342056 ENSP00000345055
ENST00000355194 ENSP00000347326
ENST00000403813 ENSP00000384453
ENST00000402622 ENSP00000385501
ENST00000443915 ENSP00000414829
ENST00000414165 ENSP00000409861
ENST00000441538 ENSP00000391971
ENST00000427928 ENSP00000388098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005242 inward rectifier potassium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
Biological Process
GO:0006461 protein complex assembly
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028033
View Gene Order
ENSBTAG00000007791
Not yet available
Pathways
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445324 Hs.679740
RefSeq NM_001160130 NM_001160132 NM_001160133 NM_001160134 NM_019842
HUGO
OMIM
CCDS CCDS4976 CCDS55034
HPRD 16241
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca