Version 5.4
Homo sapiens Gene: BUB3
Summary
InnateDB Gene IDBG-92474.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BUB3
Gene Name budding uninhibited by benzimidazoles 3 homolog (yeast)
Synonyms BUB3L; hBUB3
Species Homo sapiens
Ensembl Gene ENSG00000154473
Encoded Proteins
IDBP-92476
budding uninhibited by benzimidazoles 3 homolog (yeast)
IDBP-92478
budding uninhibited by benzimidazoles 3 homolog (yeast)
IDBP-92480
budding uninhibited by benzimidazoles 3 homolog (yeast)
IDBP-294041
budding uninhibited by benzimidazoles 3 homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:123154277-123170467
Strand Forward strand
Band q26.13
Transcripts
ENST00000368865 ENSP00000357858
ENST00000368859 ENSP00000357852
ENST00000368858 ENSP00000357851
ENST00000407911 ENSP00000383941
ENST00000481952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 65 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000278 mitotic cell cycle
GO:0007059 chromosome segregation
GO:0007094 mitotic spindle assembly checkpoint
GO:0007126 meiotic nuclear division
GO:0008608 attachment of spindle microtubules to kinetochore
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051983 regulation of chromosome segregation
GO:0071173 spindle assembly checkpoint
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066979
View Gene Order
ENSBTAG00000017913
Not yet available
Pathways
NETPATH
REACTOME
REACT_1072
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_1041
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_115566
Cell Cycle pathway
REACT_2137
Mitotic Spindle Checkpoint pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt O43684
TrEMBL J3QT28
UniProt Splice Variant
Entrez Gene 9184
UniGene Hs.645864
RefSeq NM_001007793 NM_004725
HUGO HGNC:1151
OMIM 603719
CCDS CCDS31306 CCDS7635
HPRD 04761
IMGT
EMBL AC012391 AF047472 AF047473 AF053304 AF081496 AK312546 BC005138 BC022438 CH471066
GenPept AAC06258 AAC28438 AAC28439 AAC36307 AAH05138 AAH22438 BAG35444 EAW49284 EAW49285 EAW49286
RNA Seq Atlas 9184

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca