InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BUB3

Summary

InnateDB Protein

IDBP-92476.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BUB3

Protein Name

budding uninhibited by benzimidazoles 3 homolog (yeast)

Synonyms

BUB3L; hBUB3;

Species

Homo sapiens

Ensembl Protein

ENSP00000357858

InnateDB Gene

IDBG-92474 (BUB3)

Protein Structure

UniProt Annotation

Function

Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. {ECO:0000269PubMed:10198256, ECO:0000269PubMed:15525512, ECO:0000269PubMed:18199686}.

Subcellular Localization

Nucleus. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	65 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000278	mitotic cell cycle
GO:0007059	chromosome segregation
GO:0007094	mitotic spindle assembly checkpoint
GO:0007126	meiotic nuclear division
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051983	regulation of chromosome segregation
GO:0071173	spindle assembly checkpoint