Version 5.4
Homo sapiens Gene: SLC17A5
Summary
InnateDB Gene IDBG-92538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC17A5
Gene Name solute carrier family 17 (anion/sugar transporter), member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119899
Encoded Proteins
IDBP-92540
solute carrier family 17 (anion/sugar transporter), member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:73593379-73654155
Strand Reverse strand
Band q13
Transcripts
ENST00000355773 ENSP00000348019
ENST00000481996
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005351 sugar:proton symporter activity
GO:0015136 sialic acid transmembrane transporter activity
Biological Process
GO:0006811 ion transport
GO:0006820 anion transport
GO:0006865 amino acid transport
GO:0015739 sialic acid transport
GO:0015992 proton transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049624
View Gene Order
ENSBTAG00000044053
Not yet available
Pathways
NETPATH
REACTOME
REACT_19372
Organic anion transporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597422 Hs.703047
RefSeq NM_012434 XM_005248710
HUGO
OMIM
CCDS CCDS4981
HPRD 05058
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca