InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VAMP7

Summary

InnateDB Gene

IDBG-92578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAMP7

Gene Name

vesicle-associated membrane protein 7

Synonyms

SYBL1; TI-VAMP; TIVAMP; VAMP-7

Species

Homo sapiens

Ensembl Gene

ENSG00000124333

Encoded Proteins

IDBP-92580

vesicle-associated membrane protein 7

IDBP-92582

vesicle-associated membrane protein 7

IDBP-473687

vesicle-associated membrane protein 7

IDBP-481589

vesicle-associated membrane protein 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:155881293-155943769

Strand

Forward strand

Band

q28

Transcripts

ENST00000286448	ENSP00000286448
ENST00000262640	ENSP00000262640
ENST00000479687
ENST00000488344	ENSP00000430039
ENST00000463317
ENST00000460621	ENSP00000427822

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0005515	protein binding
GO:0019905	syntaxin binding

Biological Process

GO:0006810	transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006906	vesicle fusion
GO:0006911	phagocytosis, engulfment
GO:0008333	endosome to lysosome transport
GO:0016192	vesicle-mediated transport
GO:0017156	calcium ion-dependent exocytosis
GO:0034197	triglyceride transport
GO:0035493	SNARE complex assembly
GO:0043001	Golgi to plasma membrane protein transport
GO:0043308	eosinophil degranulation
GO:0043312	neutrophil degranulation
GO:0048280	vesicle fusion with Golgi apparatus
GO:0061024	membrane organization
GO:1900483	regulation of protein targeting to vacuolar membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030658	transport vesicle membrane
GO:0030670	phagocytic vesicle membrane
GO:0031201	SNARE complex
GO:0031902	late endosome membrane
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle
GO:0045177	apical part of cell
GO:0045202	synapse
GO:0045335	phagocytic vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_19287

Lysosome Vesicle Biogenesis pathway

REACT_19400

Golgi Associated Vesicle Biogenesis pathway

REACT_19187

Clathrin derived vesicle budding pathway

REACT_11235

trans-Golgi Network Vesicle Budding pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04130

SNARE interactions in vesicular transport pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E5RH06

UniProt Splice Variant

Entrez Gene

6845

UniGene

Hs.24167 Hs.606538

RefSeq

NM_001145149 NM_001185183 NM_005638 XM_006724835 XM_006724881

HUGO

HGNC:11486

OMIM

300053

CCDS

CCDS14770 CCDS48199 CCDS55548

HPRD

02084

IMGT

EMBL

AJ271736

GenPept

RNA Seq Atlas

6845