InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VAMP7

Summary

InnateDB Protein

IDBP-92580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAMP7

Protein Name

vesicle-associated membrane protein 7

Synonyms

SYBL1; TI-VAMP; TIVAMP; VAMP-7;

Species

Homo sapiens

Ensembl Protein

ENSP00000286448

InnateDB Gene

IDBG-92578 (VAMP7)

Protein Structure

UniProt Annotation

Function

Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. {ECO:0000269PubMed:10888671, ECO:0000269PubMed:16677249, ECO:0000269PubMed:18042464}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269PubMed:17897319}; Single-pass type IV membrane protein {ECO:0000269PubMed:17897319}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in all tissues tested.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006906	vesicle fusion
GO:0006911	phagocytosis, engulfment
GO:0008333	endosome to lysosome transport
GO:0016192	vesicle-mediated transport
GO:0017156	calcium ion-dependent exocytosis
GO:0043308	eosinophil degranulation
GO:0043312	neutrophil degranulation
GO:0061024	membrane organization

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030658	transport vesicle membrane
GO:0030670	phagocytic vesicle membrane
GO:0031201	SNARE complex
GO:0031902	late endosome membrane
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle
GO:0045202	synapse
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome