InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBXW5

Summary

InnateDB Gene

IDBG-92843.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXW5

Gene Name

F-box and WD repeat domain containing 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000159069

Encoded Proteins

IDBP-92849

F-box and WD repeat domain containing 5

IDBP-384245

F-box and WD repeat domain containing 5

IDBP-384246

F-box and WD repeat domain containing 5

IDBP-811914

F-box and WD repeat domain containing 5

IDBP-811922

F-box and WD repeat domain containing 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19232515

FBXW5, an F-box family protein, negatively regulates MAP3K7 (TAK1) in the IL1B (IL-1beta) signalling pathway.

Entrez Gene

Summary

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:136940435-136944696

Strand

Reverse strand

Band

q34.3

Transcripts

ENST00000325285	ENSP00000313034
ENST00000428398	ENSP00000404829
ENST00000443788	ENSP00000394011
ENST00000459905
ENST00000483559
ENST00000487794	ENSP00000485109
ENST00000491246	ENSP00000485322
ENST00000480818

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051298	centrosome duplication

Cellular Component

GO:0005737	cytoplasm
GO:0019005	SCF ubiquitin ligase complex
GO:0080008	Cul4-RING E3 ubiquitin ligase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000015095

View Gene Order

ENSBTAG00000010515

Not yet available

Pathways

NETPATH

NetPath_13

IL1 pathway

REACTOME

REACT_16907

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_16952

Protein folding pathway

REACT_17004

Chaperonin-mediated protein folding pathway

REACT_17015

Metabolism of proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.522507

RefSeq

NM_018998 XM_005266090

HUGO

OMIM

CCDS

CCDS7014

HPRD

10955

IMGT

EMBL

GenPept

RNA Seq Atlas