InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXW5

Summary

InnateDB Protein

IDBP-92849.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXW5

Protein Name

F-box and WD repeat domain containing 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000313034

InnateDB Gene

IDBG-92843 (FBXW5)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. {ECO:0000269PubMed:18381890, ECO:0000269PubMed:19232515, ECO:0000269PubMed:21725316}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21725316}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051298	centrosome duplication