Version 5.4
Homo sapiens Gene: BCCIP
Summary
InnateDB Gene IDBG-92925.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCCIP
Gene Name BRCA2 and CDKN1A interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000107949
Encoded Proteins
IDBP-92927
BRCA2 and CDKN1A interacting protein
IDBP-92929
BRCA2 and CDKN1A interacting protein
IDBP-92931
BRCA2 and CDKN1A interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:125823546-125853695
Strand Forward strand
Band q26.2
Transcripts
ENST00000278100 ENSP00000278100
ENST00000368759 ENSP00000357748
ENST00000299130 ENSP00000299130
ENST00000463330
ENST00000478798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated
Total 46 [view]
Protein-Protein 42 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019207 kinase regulator activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006281 DNA repair
GO:0007049 cell cycle
GO:0061101 neuroendocrine cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030983
View Gene Order
ENSBTAG00000005792
Not yet available
Cross-References
SwissProt Q9P287
TrEMBL
UniProt Splice Variant
Entrez Gene 56647
UniGene Hs.665877 Hs.715543
RefSeq NM_016567 NM_078468 NM_078469
HUGO HGNC:978
OMIM 611883
CCDS CCDS7649 CCDS7650 CCDS7651
HPRD 16542
IMGT
EMBL AB040450 AB040451 AK055691 AL360176 AL834458 AY064247 AY064248 AY064249 BC009771
GenPept AAH09771 AAL55436 AAL55438 AAL55439 AAL55440 BAA92927 BAA92928 BAG51557 CAD39118 CAI12091 CAI12092 CAI12093
RNA Seq Atlas 56647

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca