InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCCIP

Summary

InnateDB Protein

IDBP-92927.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCCIP

Protein Name

BRCA2 and CDKN1A interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000278100

InnateDB Gene

IDBG-92925 (BCCIP)

Protein Structure

UniProt Annotation

Function

May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). {ECO:0000269PubMed:10878006, ECO:0000269PubMed:14726710, ECO:0000269PubMed:15539944, ECO:0000269PubMed:15713648, ECO:0000269PubMed:17947333}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10878006, ECO:0000269PubMed:11313963, ECO:0000269PubMed:15713648}. Note=Colocalizes with BRCA2 in discrete nuclear foci.

Disease Associations

Tissue Specificity

Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen. {ECO:0000269PubMed:10878006, ECO:0000269PubMed:11313963}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.

Experimentally validated
Total	46 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019207	kinase regulator activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006281	DNA repair
GO:0007049	cell cycle
GO:0061101	neuroendocrine cell differentiation