Version 5.4
| Homo sapiens Gene: COX7A2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-92966.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | COX7A2 | ||||||||||||||||||
| Gene Name | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | ||||||||||||||||||
| Synonyms | COX7AL; COX7AL1; COXVIIa-L; COXVIIAL; VIIAL | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000112695 | ||||||||||||||||||
| Encoded Proteins |
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:75237675-75250323 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q14.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Alzheimer's disease pathway
Oxidative phosphorylation pathway
Parkinson's disease pathway
Huntington's disease pathway
Cardiac muscle contraction pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | D6R9C3 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 1347 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001865 XM_006715335 | ||||||||||||||||||
| HUGO | HGNC:2288 | ||||||||||||||||||
| OMIM | 123996 | ||||||||||||||||||
| CCDS | CCDS34486 | ||||||||||||||||||
| HPRD | 00482 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AL080250 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 1347 | ||||||||||||||||||