Version 5.4
Homo sapiens Gene: MGMT
Summary
InnateDB Gene IDBG-93188.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGMT
Gene Name O-6-methylguanine-DNA methyltransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170430
Encoded Proteins
IDBP-93190
O-6-methylguanine-DNA methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:129467184-129768007
Strand Forward strand
Band q26.3
Transcripts
ENST00000306010 ENSP00000302111
ENST00000482653
ENST00000482547
ENST00000462672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
Experimentally validated
Total 80 [view]
Protein-Protein 78 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0005509 calcium ion binding
GO:0008168 methyltransferase activity
GO:0009008 DNA-methyltransferase activity
Biological Process
GO:0006266 DNA ligation
GO:0006281 DNA repair
GO:0006306 DNA methylation
GO:0006307 DNA dealkylation involved in DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0034599 cellular response to oxidative stress
GO:0042493 response to drug
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045471 response to ethanol
GO:0045739 positive regulation of DNA repair
GO:0051593 response to folic acid
GO:0060548 negative regulation of cell death
GO:0060644 mammary gland epithelial cell differentiation
GO:0071407 cellular response to organic cyclic compound
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000054612
View Gene Order
Pathways
NETPATH
REACTOME
REACT_127
DNA Damage Reversal pathway
REACT_216
DNA Repair pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.501522
RefSeq NM_002412 XM_006717863
HUGO
OMIM
CCDS CCDS7660
HPRD 01135
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca