Version 5.4
Homo sapiens Protein: MGMT
Summary
InnateDB Protein IDBP-93190.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGMT
Protein Name O-6-methylguanine-DNA methyltransferase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302111
InnateDB Gene IDBG-93188 (MGMT)
Protein Structure
UniProt Annotation
Function Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
Experimentally validated
Total 80 [view]
Protein-Protein 78 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0005509 calcium ion binding
GO:0008168 methyltransferase activity
GO:0009008 DNA-methyltransferase activity
Biological Process
GO:0006266 DNA ligation
GO:0006281 DNA repair
GO:0006306 DNA methylation
GO:0006307 DNA dealkylation involved in DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0034599 cellular response to oxidative stress
GO:0042493 response to drug
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045471 response to ethanol
GO:0045739 positive regulation of DNA repair
GO:0051593 response to folic acid
GO:0060548 negative regulation of cell death
GO:0060644 mammary gland epithelial cell differentiation
GO:0071407 cellular response to organic cyclic compound
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain
IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
PFAM PF02870
PF01035
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P16455
PhosphoSite PhosphoSite-P16455
TrEMBL Q6LDD1
UniProt Splice Variant
Entrez Gene 4255
UniGene Hs.501522
RefSeq NP_002403
HUGO HGNC:7059
OMIM 156569
CCDS CCDS7660
HPRD 01135
IMGT
EMBL AK293593 AL157832 AL355531 BC000824 BT006714 CH471066 M29971 M31767 M60761 S52068 X54228
GenPept AAA52317 AAA59594 AAA59596 AAD13867 AAH00824 AAP35360 BAG57059 CAA38137 CAH70060 CAH72190 EAW49166

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca