Version 5.4
Homo sapiens Gene: NELF
Summary
InnateDB Gene IDBG-93368.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NELF
Gene Name nasal embryonic LHRH factor
Synonyms HH9; NELF
Species Homo sapiens
Ensembl Gene ENSG00000165802
Encoded Proteins
IDBP-93370
nasal embryonic LHRH factor
IDBP-93372
nasal embryonic LHRH factor
IDBP-93374
nasal embryonic LHRH factor
IDBP-93376
nasal embryonic LHRH factor
IDBP-93378
nasal embryonic LHRH factor
IDBP-93380
nasal embryonic LHRH factor
IDBP-93382
nasal embryonic LHRH factor
IDBP-93384
nasal embryonic LHRH factor
IDBP-384611
nasal embryonic LHRH factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137447570-137459334
Strand Reverse strand
Band q34.3
Transcripts
ENST00000339554 ENSP00000342966
ENST00000371482 ENSP00000360537
ENST00000371475 ENSP00000360530
ENST00000265663 ENSP00000265663
ENST00000371474 ENSP00000360529
ENST00000371473 ENSP00000360528
ENST00000371472 ENSP00000360527
ENST00000371468 ENSP00000360523
ENST00000437259 ENSP00000412007
ENST00000484316
ENST00000482448
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0035307 positive regulation of protein dephosphorylation
GO:0043523 regulation of neuron apoptotic process
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048814 regulation of dendrite morphogenesis
GO:0071230 cellular response to amino acid stimulus
GO:0071257 cellular response to electrical stimulus
GO:0071371 cellular response to gonadotropin stimulus
GO:2001224 positive regulation of neuron migration
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005719 nuclear euchromatin
GO:0005737 cytoplasm
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0030054 cell junction
GO:0030425 dendrite
GO:0030863 cortical cytoskeleton
GO:0031965 nuclear membrane
GO:0043005 neuron projection
GO:0043204 perikaryon
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0097440 apical dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006476
View Gene Order
ENSBTAG00000030247
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.455336
RefSeq NM_001130969 NM_001130970 NM_001130971 NM_001178064 NM_015537 XM_005266061
HUGO
OMIM
CCDS CCDS48067 CCDS48068 CCDS48069 CCDS55357 CCDS7044
HPRD 10485
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca