Version 5.4
Homo sapiens Gene: CDC42
Summary
InnateDB Gene IDBG-93614.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42
Gene Name cell division cycle 42 (GTP binding protein, 25kDa)
Synonyms CDC42Hs; G25K
Species Homo sapiens
Ensembl Gene ENSG00000070831
Encoded Proteins
IDBP-93618
cell division cycle 42 (GTP binding protein, 25kDa)
IDBP-93620
cell division cycle 42 (GTP binding protein, 25kDa)
IDBP-228704
cell division cycle 42 (GTP binding protein, 25kDa)
IDBP-374536
cell division cycle 42 (GTP binding protein, 25kDa)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23690402
[Mus musculus] Cdc42 has a critical role in mediating innate immunity against upper airway infections.
Entrez Gene
Summary The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:22052627-22092946
Strand Forward strand
Band p36.12
Transcripts
ENST00000344548 ENSP00000341072
ENST00000315554 ENSP00000314458
ENST00000400259 ENSP00000383118
ENST00000411827 ENSP00000398327
ENST00000498236
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 221 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 221 [view]
Protein-Protein 220 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019901 protein kinase binding
GO:0030742 GTP-dependent protein binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031996 thioesterase binding
GO:0034191 apolipoprotein A-I receptor binding
GO:0042802 identical protein binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002040 sprouting angiogenesis
GO:0003161 cardiac conduction system development
GO:0003334 keratinocyte development
GO:0006184 GTP catabolic process
GO:0007015 actin filament organization
GO:0007030 Golgi organization
GO:0007088 regulation of mitosis
GO:0007097 nuclear migration
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0015031 protein transport
GO:0021762 substantia nigra development
GO:0030036 actin cytoskeleton organization
GO:0030225 macrophage differentiation
GO:0031069 hair follicle morphogenesis
GO:0031274 positive regulation of pseudopodium assembly
GO:0031295 T cell costimulation
GO:0031333 negative regulation of protein complex assembly
GO:0031424 keratinization
GO:0031647 regulation of protein stability
GO:0032467 positive regulation of cytokinesis
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034332 adherens junction organization
GO:0034613 cellular protein localization
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0035264 multicellular organism growth
GO:0036336 dendritic cell migration
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042176 regulation of protein catabolic process
GO:0042692 muscle cell differentiation
GO:0043410 positive regulation of MAPK cascade
GO:0043497 regulation of protein heterodimerization activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045740 positive regulation of DNA replication
GO:0045859 regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0046847 filopodium assembly
GO:0048554 positive regulation of metalloenzyme activity
GO:0048664 neuron fate determination
GO:0048730 epidermis morphogenesis
GO:0051017 actin filament bundle assembly
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051149 positive regulation of muscle cell differentiation
GO:0051246 regulation of protein metabolic process
GO:0051489 regulation of filopodium assembly
GO:0051647 nucleus localization
GO:0051683 establishment of Golgi localization
GO:0051835 positive regulation of synapse structural plasticity
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0060047 heart contraction
GO:0060070 canonical Wnt signaling pathway
GO:0060661 submandibular salivary gland formation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0060789 hair follicle placode formation
GO:0071338 positive regulation of hair follicle cell proliferation
GO:0072384 organelle transport along microtubule
GO:0090135 actin filament branching
GO:0090136 epithelial cell-cell adhesion
GO:0090316 positive regulation of intracellular protein transport
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0030141 secretory granule
GO:0030175 filopodium
GO:0030496 midbody
GO:0031256 leading edge membrane
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
GO:0051233 spindle midzone
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006699
View Gene Order
ENSBTAG00000001700
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_19238
CD28 dependent Vav1 pathway pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_21402
CDO in myogenesis pathway
REACT_22351
DCC mediated attractive signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_19342
Inactivation of Cdc42 and Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_19271
Semaphorin interactions pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_12529
Signaling by VEGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21303
Myogenesis pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04912
GnRH signaling pathway pathway
hsa04370
VEGF signaling pathway pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05212
Pancreatic cancer pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
netrin_pathway
Netrin-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
erbb1_internalization_pathway
Internalization of ErbB1
erbb1_downstream_pathway
ErbB1 downstream signaling
nectin_pathway
Nectin adhesion pathway
ilk_pathway
Integrin-linked kinase signaling
ephbfwdpathway
EPHB forward signaling
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
cdc42_pathway
CDC42 signaling events
s1p_s1p4_pathway
S1P4 pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
cdc42_reg_pathway
Regulation of CDC42 activity
rhoa_pathway
RhoA signaling pathway
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467637
RefSeq NM_001039802 NM_001791 NM_044472
HUGO
OMIM
CCDS CCDS221 CCDS222
HPRD 00309
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca