InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC42

Summary

InnateDB Protein

IDBP-228704.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC42

Protein Name

cell division cycle 42 (GTP binding protein, 25kDa)

Synonyms

CDC42Hs; G25K;

Species

Homo sapiens

Ensembl Protein

ENSP00000383118

InnateDB Gene

IDBG-93614 (CDC42)

Protein Structure

UniProt Annotation

Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. {ECO:0000269PubMed:14978216, ECO:0000269PubMed:15642749, ECO:0000269PubMed:17038317}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 221 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	221 [view]
Protein-Protein	220 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019901	protein kinase binding
GO:0030742	GTP-dependent protein binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0031996	thioesterase binding
GO:0034191	apolipoprotein A-I receptor binding
GO:0042802	identical protein binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002040	sprouting angiogenesis
GO:0003161	cardiac conduction system development
GO:0003334	keratinocyte development
GO:0006184	GTP catabolic process
GO:0007015	actin filament organization
GO:0007030	Golgi organization
GO:0007088	regulation of mitosis
GO:0007097	nuclear migration
GO:0007163	establishment or maintenance of cell polarity
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0015031	protein transport
GO:0021762	substantia nigra development
GO:0030036	actin cytoskeleton organization
GO:0030225	macrophage differentiation
GO:0031069	hair follicle morphogenesis
GO:0031274	positive regulation of pseudopodium assembly
GO:0031295	T cell costimulation
GO:0031333	negative regulation of protein complex assembly
GO:0031424	keratinization
GO:0031647	regulation of protein stability
GO:0032467	positive regulation of cytokinesis
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034332	adherens junction organization
GO:0034613	cellular protein localization
GO:0035088	establishment or maintenance of apical/basal cell polarity
GO:0035264	multicellular organism growth
GO:0036336	dendritic cell migration
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042176	regulation of protein catabolic process
GO:0042692	muscle cell differentiation
GO:0043410	positive regulation of MAPK cascade
GO:0043497	regulation of protein heterodimerization activity
GO:0043525	positive regulation of neuron apoptotic process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087	innate immune response
GO:0045740	positive regulation of DNA replication
GO:0045859	regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0046847	filopodium assembly
GO:0048554	positive regulation of metalloenzyme activity
GO:0048664	neuron fate determination
GO:0048730	epidermis morphogenesis
GO:0051017	actin filament bundle assembly
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051149	positive regulation of muscle cell differentiation
GO:0051246	regulation of protein metabolic process
GO:0051489	regulation of filopodium assembly
GO:0051647	nucleus localization
GO:0051683	establishment of Golgi localization
GO:0051835	positive regulation of synapse structural plasticity
GO:0051988	regulation of attachment of spindle microtubules to kinetochore
GO:0060047	heart contraction
GO:0060070	canonical Wnt signaling pathway
GO:0060661	submandibular salivary gland formation
GO:0060684	epithelial-mesenchymal cell signaling
GO:0060789	hair follicle placode formation
GO:0071338	positive regulation of hair follicle cell proliferation
GO:0072384	organelle transport along microtubule
GO:0090135	actin filament branching
GO:0090136	epithelial cell-cell adhesion
GO:0090316	positive regulation of intracellular protein transport
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0030141	secretory granule
GO:0030175	filopodium
GO:0030496	midbody
GO:0031256	leading edge membrane
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0051233	spindle midzone
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery
GO:0072686	mitotic spindle

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt