Version 5.4
Homo sapiens Gene: PAOX
Summary
InnateDB Gene IDBG-93753.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAOX
Gene Name polyamine oxidase (exo-N4-amino)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148832
Encoded Proteins
IDBP-93755
polyamine oxidase (exo-N4-amino)
IDBP-93757
polyamine oxidase (exo-N4-amino)
IDBP-93763
polyamine oxidase (exo-N4-amino)
IDBP-93765
polyamine oxidase (exo-N4-amino)
IDBP-600424
polyamine oxidase (exo-N4-amino)
IDBP-601562
polyamine oxidase (exo-N4-amino)
IDBP-594798
polyamine oxidase (exo-N4-amino)
IDBP-589804
polyamine oxidase (exo-N4-amino)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:133379234-133391694
Strand Forward strand
Band q26.3
Transcripts
ENST00000278060 ENSP00000278060
ENST00000357296 ENSP00000349847
ENST00000356306 ENSP00000348654
ENST00000368539 ENSP00000357527
ENST00000368535
ENST00000483211 ENSP00000434550
ENST00000476834 ENSP00000432737
ENST00000480071 ENSP00000435514
ENST00000529585 ENSP00000432517
ENST00000528127
ENST00000530555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0016491 oxidoreductase activity
GO:0046592 polyamine oxidase activity
GO:0052899 N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052901 spermine:oxygen oxidoreductase (spermidine-forming) activity
GO:0052902 spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
GO:0052903 N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052904 N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0006598 polyamine catabolic process
GO:0006805 xenobiotic metabolic process
GO:0009446 putrescine biosynthetic process
GO:0009447 putrescine catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0046203 spermidine catabolic process
GO:0046208 spermine catabolic process
GO:0055114 oxidation-reduction process
GO:1901307 positive regulation of spermidine biosynthetic process
Cellular Component
GO:0005782 peroxisomal matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025464
View Gene Order
ENSBTAG00000018321
Not yet available
Pathways
NETPATH
REACTOME
REACT_14805
Interconversion of polyamines pathway
REACT_14820
Metabolism of polyamines pathway
REACT_505
PAOs oxidise polyamines to amines pathway
REACT_1875
Amine Oxidase reactions pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt Q6QHF9
TrEMBL
UniProt Splice Variant
Entrez Gene 196743
UniGene Hs.532469
RefSeq NM_152911 NM_207127 NM_207128
HUGO HGNC:20837
OMIM 615853
CCDS CCDS7682 CCDS7683 CCDS7684
HPRD 10136
IMGT
EMBL AF226657 AF312698 AL360181 AL834535 AY358418 AY541513 AY541514 AY541515 AY541516 AY541517 AY541518 AY541519 AY541520 AY541521 AY541522 AY541523 AY541524 BC032778 CH471211
GenPept AAH32778 AAN40706 AAO63265 AAQ88784 AAS64373 AAS64374 AAS64375 AAS64376 AAS64377 AAS64378 AAS64379 AAS64380 AAS64381 AAS64382 AAS64383 AAS64384 CAD39191 CAH70287 EAW61340 EAW61341 EAW61344
RNA Seq Atlas 196743

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca