InnateDB Protein
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IDBP-589804.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PAOX
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Protein Name
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polyamine oxidase (exo-N4-amino)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000432517
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InnateDB Gene
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IDBG-93753 (PAOX)
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Protein Structure
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Function |
Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
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Subcellular Localization |
Peroxisome {ECO:0000250}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues. {ECO:0000269PubMed:12477380}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005102
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receptor binding
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GO:0016491
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oxidoreductase activity
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GO:0046592
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polyamine oxidase activity
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GO:0052899
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N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
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GO:0052901
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spermine:oxygen oxidoreductase (spermidine-forming) activity
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GO:0052902
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spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
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GO:0052903
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N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
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GO:0052904
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N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002937
Amine oxidase
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PFAM |
PF01593
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6QHF9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
196743
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UniGene |
Hs.532469
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RefSeq |
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HUGO |
HGNC:20837
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OMIM |
615853
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CCDS |
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HPRD |
10136
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IMGT |
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EMBL |
AF226657
AF312698
AL360181
AL834535
AY358418
AY541513
AY541514
AY541515
AY541516
AY541517
AY541518
AY541519
AY541520
AY541521
AY541522
AY541523
AY541524
BC032778
CH471211
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GenPept |
AAH32778
AAN40706
AAO63265
AAQ88784
AAS64373
AAS64374
AAS64375
AAS64376
AAS64377
AAS64378
AAS64379
AAS64380
AAS64381
AAS64382
AAS64383
AAS64384
CAD39191
CAH70287
EAW61340
EAW61341
EAW61344
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