InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPHB2

Summary

InnateDB Gene

IDBG-93774.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHB2

Gene Name

EPH receptor B2

Synonyms

CAPB; DRT; EK5; EPHT3; ERK; Hek5; PCBC; Tyro5

Species

Homo sapiens

Ensembl Gene

ENSG00000133216

Encoded Proteins

IDBP-93776

EPH receptor B2

IDBP-93778

EPH receptor B2

IDBP-93780

EPH receptor B2

IDBP-228761

EPH receptor B2

IDBP-602167

EPH receptor B2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:22710839-22915325

Strand

Forward strand

Band

p36.12

Transcripts

ENST00000374632	ENSP00000363763
ENST00000374630	ENSP00000363761
ENST00000374627	ENSP00000363758
ENST00000400191	ENSP00000383053
ENST00000465676
ENST00000490436
ENST00000544305	ENSP00000444174

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000902	cell morphogenesis
GO:0001525	angiogenesis
GO:0001655	urogenital system development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0007612	learning
GO:0009887	organ morphogenesis
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021631	optic nerve morphogenesis
GO:0021952	central nervous system projection neuron axonogenesis
GO:0022038	corpus callosum development
GO:0031290	retinal ganglion cell axon guidance
GO:0042472	inner ear morphogenesis
GO:0048013	ephrin receptor signaling pathway
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048170	positive regulation of long-term neuronal synaptic plasticity
GO:0048593	camera-type eye morphogenesis
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis
GO:0050878	regulation of body fluid levels
GO:0051965	positive regulation of synapse assembly
GO:0060021	palate development
GO:0060996	dendritic spine development
GO:0060997	dendritic spine morphogenesis
GO:0071679	commissural neuron axon guidance