Version 5.4
Homo sapiens Gene: PGM3
Summary
InnateDB Gene IDBG-93783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGM3
Gene Name phosphoglucomutase 3
Synonyms AGM1; IMD23; PAGM; PGM 3
Species Homo sapiens
Ensembl Gene ENSG00000013375
Encoded Proteins
IDBP-93787
phosphoglucomutase 3
IDBP-484577
phosphoglucomutase 3
IDBP-479293
phosphoglucomutase 3
IDBP-473872
phosphoglucomutase 3
IDBP-478230
phosphoglucomutase 3
IDBP-479651
phosphoglucomutase 3
IDBP-474553
phosphoglucomutase 3
IDBP-477225
phosphoglucomutase 3
IDBP-485046
phosphoglucomutase 3
IDBP-480310
phosphoglucomutase 3
IDBP-484082
phosphoglucomutase 3
IDBP-812452
phosphoglucomutase 3
IDBP-812453
phosphoglucomutase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:83161150-83193936
Strand Reverse strand
Band q14.1
Transcripts
ENST00000283977 ENSP00000283977
ENST00000504780 ENSP00000421154
ENST00000513973 ENSP00000424874
ENST00000512866 ENSP00000421565
ENST00000506587 ENSP00000425809
ENST00000509219 ENSP00000423389
ENST00000507404
ENST00000510258 ENSP00000427420
ENST00000505470 ENSP00000423769
ENST00000507554 ENSP00000425558
ENST00000508748 ENSP00000424865
ENST00000503094 ENSP00000422362
ENST00000515333
ENST00000605602 ENSP00000474029
ENST00000616566 ENSP00000477539
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004610 phosphoacetylglucosamine mutase activity
GO:0004614 phosphoglucomutase activity
GO:0016868 intramolecular transferase activity, phosphotransferases
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006041 glucosamine metabolic process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0007283 spermatogenesis
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019255 glucose 1-phosphate metabolic process
GO:0030097 hemopoiesis
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056131
View Gene Order
ENSBTAG00000000679
Not yet available
Pathways
NETPATH
REACTOME
REACT_22394
Synthesis of UDP-N-acetyl-glucosamine pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
INOH website
Aminosugars metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.661665
RefSeq NM_001199917 NM_001199918 NM_001199919 NM_015599 XM_005248728 XM_006715504
HUGO
OMIM
CCDS CCDS4997 CCDS56435 CCDS56436 CCDS75487
HPRD 01390
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca