Version 5.4
Homo sapiens Gene: RAPGEF5
Summary
InnateDB Gene IDBG-9388.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAPGEF5
Gene Name Rap guanine nucleotide exchange factor (GEF) 5
Synonyms GFR; MR-GEF; REPAC
Species Homo sapiens
Ensembl Gene ENSG00000136237
Encoded Proteins
IDBP-9390
Rap guanine nucleotide exchange factor (GEF) 5
IDBP-294937
Rap guanine nucleotide exchange factor (GEF) 5
IDBP-294935
Rap guanine nucleotide exchange factor (GEF) 5
IDBP-367542
Rap guanine nucleotide exchange factor (GEF) 5
IDBP-367545
Rap guanine nucleotide exchange factor (GEF) 5
IDBP-367552
Rap guanine nucleotide exchange factor (GEF) 5
IDBP-809979
Rap guanine nucleotide exchange factor (GEF) 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:22118238-22357144
Strand Reverse strand
Band p15.3
Transcripts
ENST00000344041 ENSP00000343656
ENST00000401957 ENSP00000384044
ENST00000405243 ENSP00000384870
ENST00000458533 ENSP00000415664
ENST00000451559 ENSP00000403956
ENST00000420196 ENSP00000395729
ENST00000488366
ENST00000468825
ENST00000475788
ENST00000471484
ENST00000497668
ENST00000620335 ENSP00000479340
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0017034 Rap guanyl-nucleotide exchange factor activity
GO:0030742 GTP-dependent protein binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0007399 nervous system development
GO:0032320 positive regulation of Ras GTPase activity
GO:0032854 positive regulation of Rap GTPase activity
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041992
View Gene Order
ENSBTAG00000015539
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.174768 Hs.602827 Hs.713217
RefSeq NM_012294 XM_005249914 XM_005249915 XM_005249916 XM_005249917
HUGO
OMIM
CCDS CCDS55093
HPRD 15208
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca