InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAPGEF5

Summary

InnateDB Protein

IDBP-294937.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAPGEF5

Protein Name

Rap guanine nucleotide exchange factor (GEF) 5

Synonyms

GFR; MR-GEF; REPAC;

Species

Homo sapiens

Ensembl Protein

ENSP00000384044

InnateDB Gene

IDBG-9388 (RAPGEF5)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. {ECO:0000269PubMed:10777494, ECO:0000269PubMed:10934204}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0017034	Rap guanyl-nucleotide exchange factor activity
GO:0030742	GTP-dependent protein binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0007399	nervous system development
GO:0032320	positive regulation of Ras GTPase activity
GO:0032854	positive regulation of Rap GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain
IPR029071 Ubiquitin-related domain

PFAM

PF00618
PF00617

PRINTS

PIRSF

SMART

SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92565