Version 5.4
Homo sapiens Gene: ORC3
Summary
InnateDB Gene IDBG-94195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORC3
Gene Name origin recognition complex, subunit 3
Synonyms LAT; LATHEO; ORC3L
Species Homo sapiens
Ensembl Gene ENSG00000135336
Encoded Proteins
IDBP-94197
origin recognition complex, subunit 3
IDBP-244828
origin recognition complex, subunit 3
IDBP-590064
origin recognition complex, subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:87590067-87667453
Strand Forward strand
Band q15
Transcripts
ENST00000257789 ENSP00000257789
ENST00000392844 ENSP00000376586
ENST00000468486
ENST00000478028
ENST00000546266 ENSP00000444695
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 44 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0061351 neural precursor cell proliferation
Cellular Component
GO:0000808 origin recognition complex
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040044
View Gene Order
ENSBTAG00000016969
Not yet available
Pathways
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_1181
Association of licensing factors with the pre-replicative complex pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1707
CDC6 association with the ORC:origin complex pathway
REACT_1949
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_567
Assembly of the ORC complex at the origin of replication pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_1321
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_829
Regulation of DNA replication pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.410228 Hs.603122 Hs.735758
RefSeq NM_001197259 NM_012381 NM_181837 XM_005248704 XM_005248705 XM_005248706
HUGO
OMIM
CCDS CCDS43486 CCDS5012 CCDS56440
HPRD 05398
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca