Version 5.4
| Mus musculus Gene: Orc3 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-134938.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Orc3 | ||||||||||||||||||||||
| Gene Name | origin recognition complex, subunit 3 | ||||||||||||||||||||||
| Synonyms | Orc3l | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000040044 | ||||||||||||||||||||||
| Encoded Proteins |
origin recognition complex, subunit 3
origin recognition complex, subunit 3
origin recognition complex, subunit 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135336:
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 4:34570796-34614944 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | A5 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Assembly of the ORC complex at the origin of replication pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
CDT1 association with the CDC6:ORC:origin complex pathway
DNA Replication pathway
Switching of origins to a post-replicative state pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Activation of the pre-replicative complex pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
E2F-enabled inhibition of pre-replication complex formation pathway
Association of licensing factors with the pre-replicative complex pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
E2F mediated regulation of DNA replication pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
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| KEGG |
Cell cycle pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Activation of ATR in response to replication stress pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Association of licensing factors with the pre-replicative complex pathway
Switching of origins to a post-replicative state pathway
Activation of the pre-replicative complex pathway
CDC6 association with the ORC:origin complex pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Assembly of the ORC complex at the origin of replication pathway
Assembly of the pre-replicative complex pathway
E2F-enabled inhibition of pre-replication complex formation pathway
E2F mediated regulation of DNA replication pathway
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Cell Cycle pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
Regulation of DNA replication pathway
Cell Cycle Checkpoints pathway
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| KEGG |
Cell cycle pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | Q9JK30 | ||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 50793 | ||||||||||||||||||||||
| UniGene | Mm.399624 | ||||||||||||||||||||||
| RefSeq | NM_001159563 NM_015824 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS51137 CCDS18028 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:1354944 | ||||||||||||||||||||||
| MGI Symbol | Orc3 | ||||||||||||||||||||||
| EMBL | AB190257 AJ132830 AK045388 AK086579 AL807397 AL928738 BC061252 | ||||||||||||||||||||||
| GenPept | AAH61252 BAC32339 BAC39695 BAD91665 CAB76399 CAM16474 CAM16475 CAM26869 CAM26870 | ||||||||||||||||||||||
| RNA Seq Atlas | 50793 | ||||||||||||||||||||||