Version 5.4
Homo sapiens Gene: SEPX1
Summary
InnateDB Gene IDBG-9424.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPX1
Gene Name methionine sulfoxide reductase B1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198736
Encoded Proteins
IDBP-9426
selenoprotein X, 1
IDBP-229834
selenoprotein X, 1
IDBP-753593
IDBP-750696
IDBP-808691
methionine sulfoxide reductase B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase (Msr) protein family which includes repair enzymes that reduce oxidized methionine residues in proteins. The protein encoded by this gene is expressed in a variety of adult and fetal tissues and localizes to the cell nucleus and cytosol. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1938210-1943326
Strand Reverse strand
Band p13.3
Transcripts
ENST00000361871 ENSP00000355084
ENST00000399753 ENSP00000382657
ENST00000473663 ENSP00000457320
ENST00000489198
ENST00000564908 ENSP00000456557
ENST00000622125 ENSP00000480943
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008270 zinc ion binding
GO:0033743 peptide-methionine (R)-S-oxide reductase activity
GO:0070191 methionine-R-sulfoxide reductase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0030041 actin filament polymerization
GO:0030091 protein repair
GO:0045087 innate immune response
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000075705
View Gene Order
Cross-References
SwissProt Q9NZV6
TrEMBL A8MYR2 D3DU81 H3BS64
UniProt Splice Variant
Entrez Gene 51734
UniGene
RefSeq NM_016332
HUGO HGNC:14133
OMIM 606216
CCDS CCDS42100
HPRD
IMGT
EMBL AC005363 AE006640 AF161388 AF166124 AF187272 BC003127 CH471112
GenPept AAF21429 AAF28948 AAG17033 AAH03127 AAK61300 EAW85600 EAW85601
RNA Seq Atlas 51734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca