Version 5.4
Homo sapiens Gene: FHL5
Summary
InnateDB Gene IDBG-94463.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FHL5
Gene Name four and a half LIM domains 5
Synonyms ACT; dJ393D12.2
Species Homo sapiens
Ensembl Gene ENSG00000112214
Encoded Proteins
IDBP-94465
four and a half LIM domains 5
IDBP-385470
four and a half LIM domains 5
IDBP-594053
four and a half LIM domains 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:96562548-96616636
Strand Forward strand
Band q16.1
Transcripts
ENST00000326771 ENSP00000326022
ENST00000450218 ENSP00000396390
ENST00000541107 ENSP00000442357
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028259
View Gene Order
ENSBTAG00000001803
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q5TD97
TrEMBL X6RED3
UniProt Splice Variant
Entrez Gene 9457
UniGene Hs.632608
RefSeq NM_020482 NM_001170807 XM_006715613
HUGO HGNC:17371
OMIM 605126
CCDS CCDS5035
HPRD 05497
IMGT
EMBL AF278541 AK057611 AK223539 AK314608 AL132776 BC021723 BC029490 CH471051
GenPept AAF85978 AAH21723 AAH29490 BAD97259 BAG37178 BAG51940 CAB86657 CAI20400 EAW48503 EAW48504 EAW48505
RNA Seq Atlas 9457

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca