Homo sapiens Gene: FBXL4
Summary
InnateDB Gene IDBG-94524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL4
Gene Name F-box and leucine-rich repeat protein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112234
Encoded Proteins
F-box and leucine-rich repeat protein 4
F-box and leucine-rich repeat protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 9 tandem leucine-rich repeats. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:98868538-98948006
Strand Reverse strand
Band q16.2
Transcripts
ENST00000369244 ENSP00000358247
ENST00000229971 ENSP00000229971
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005758 mitochondrial intermembrane space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q9UKA2
TrEMBL
UniProt Splice Variant
Entrez Gene 26235
UniGene Hs.734936
RefSeq NM_001278716 NM_012160 XM_006715458
HUGO HGNC:13601
OMIM 605654
CCDS CCDS5041
HPRD 05738
IMGT
EMBL AF174590 AF176699 AF199355 AK313076 AL022395 BC055010 BC091484 CH471051
GenPept AAF03699 AAF04511 AAF09247 AAH55010 AAH91484 BAG35902 CAB37981 EAW48489 EAW48490
RNA Seq Atlas 26235