Homo sapiens Gene: HMGN2
Summary
InnateDB Gene IDBG-94677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGN2
Gene Name high mobility group nucleosomal binding domain 2
Synonyms HMG17
Species Homo sapiens
Ensembl Gene ENSG00000198830
Encoded Proteins
high mobility group nucleosomal binding domain 2
high mobility group nucleosomal binding domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
HMGN2 acts as a positive modulator of NF-kB signalling to promote LPS-induced beta-defensin expression. HMGN2 prolongs the retention time and enhances the accumulation of NF-kB p65 and synergistically bind to the DEFB4A (HBD-2 ) promoter to induce expression.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:26472450-26475972
Strand Forward strand
Band p36.11
Transcripts
ENST00000361427 ENSP00000355228
ENST00000468388
ENST00000479815
ENST00000460563
ENST00000464888
ENST00000463817
ENST00000467700
ENST00000466194
ENST00000493418
ENST00000619352 ENSP00000481160
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0031492 nucleosomal DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
TSH pathway
Prolactin pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.181163 Hs.600177 Hs.602789 Hs.605991 Hs.716454 Hs.717957 Hs.723435 Hs.738551
RefSeq NM_005517
HUGO
OMIM
CCDS CCDS283
HPRD 01230
IMGT
EMBL
GenPept
RNA Seq Atlas