Version 5.4
Homo sapiens Protein: HMGN2
Summary
InnateDB Protein IDBP-94679.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGN2
Protein Name high mobility group nucleosomal binding domain 2
Synonyms HMG17;
Species Homo sapiens
Ensembl Protein ENSP00000355228
InnateDB Gene IDBG-94677 (HMGN2)
Protein Structure
UniProt Annotation
Function Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10739259}. Cytoplasm {ECO:0000269PubMed:10739259}. Note=Cytoplasmic enrichment upon phosphorylation.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0031492 nucleosomal DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000079 High mobility group nucleosome-binding domain-containing family
PFAM PF01101
PRINTS PR00925
PIRSF
SMART SM00527
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P05204
PhosphoSite PhosphoSite-P05204
TrEMBL
UniProt Splice Variant
Entrez Gene 3151
UniGene Hs.738551
RefSeq NP_005508
HUGO HGNC:4986
OMIM 163910
CCDS CCDS283
HPRD 01230
IMGT
EMBL AL513365 BC000378 BC003050 BC014644 BC032140 BC070297 BC071707 BC072010 BC072011 BC075837 BC081567 BC110390 CR542122 M12623 X13546
GenPept AAA52678 AAH00378 AAH03050 AAH14644 AAH32140 AAH70297 AAH71707 AAH72010 AAH72011 AAH75837 AAH81567 AAI10391 CAA31898 CAG46919 CAI21489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca