Version 5.4
Homo sapiens Gene: PDSS2
Summary
InnateDB Gene IDBG-94918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDSS2
Gene Name prenyl (decaprenyl) diphosphate synthase, subunit 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164494
Encoded Proteins
IDBP-94920
prenyl (decaprenyl) diphosphate synthase, subunit 2
IDBP-94926
prenyl (decaprenyl) diphosphate synthase, subunit 2
IDBP-385745
prenyl (decaprenyl) diphosphate synthase, subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:107152557-107459564
Strand Reverse strand
Band q21
Transcripts
ENST00000369037 ENSP00000358033
ENST00000369031 ENSP00000358027
ENST00000449027 ENSP00000392613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000010 trans-hexaprenyltranstransferase activity
GO:0046982 protein heterodimerization activity
GO:0050347 trans-octaprenyltranstransferase activity
Biological Process
GO:0006744 ubiquinone biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0044281 small molecule metabolic process
GO:0050878 regulation of body fluid levels
GO:0051290 protein heterotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038240
View Gene Order
ENSBTAG00000021859
Not yet available
Pathways
NETPATH
REACTOME
REACT_160111
Ubiquinol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5JRD6
UniProt Splice Variant
Entrez Gene 57107
UniGene Hs.486095 Hs.743404
RefSeq NM_020381
HUGO HGNC:23041
OMIM 610564
CCDS CCDS5059
HPRD 12879
IMGT
EMBL AL121957 AL355586 AL590489 AL591516
GenPept
RNA Seq Atlas 57107

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca