Version 5.4
Homo sapiens Gene: WISP3
Summary
InnateDB Gene IDBG-95510.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WISP3
Gene Name WNT1 inducible signaling pathway protein 3
Synonyms CCN6; LIBC; PPAC; PPD
Species Homo sapiens
Ensembl Gene ENSG00000112761
Encoded Proteins
IDBP-95512
WNT1 inducible signaling pathway protein 3
IDBP-95514
WNT1 inducible signaling pathway protein 3
IDBP-95516
WNT1 inducible signaling pathway protein 3
IDBP-95520
WNT1 inducible signaling pathway protein 3
IDBP-95522
WNT1 inducible signaling pathway protein 3
IDBP-293477
WNT1 inducible signaling pathway protein 3
IDBP-386203
WNT1 inducible signaling pathway protein 3
IDBP-812258
WNT1 inducible signaling pathway protein 3
IDBP-812276
WNT1 inducible signaling pathway protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:112054072-112070969
Strand Forward strand
Band q21
Transcripts
ENST00000230529 ENSP00000230529
ENST00000361714 ENSP00000354734
ENST00000368666 ENSP00000357655
ENST00000368664 ENSP00000357653
ENST00000368663 ENSP00000357652
ENST00000409166 ENSP00000386467
ENST00000454589 ENSP00000395928
ENST00000483439
ENST00000604763 ENSP00000473777
ENST00000613648
ENST00000620524 ENSP00000478049
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005520 insulin-like growth factor binding
GO:0008083 growth factor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062074
View Gene Order
ENSBTAG00000017205
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.558428 Hs.672389
RefSeq NM_003880 NM_198239 XM_006715590
HUGO
OMIM
CCDS CCDS5097 CCDS5098
HPRD 04550
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca