InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WISP3

Summary

InnateDB Protein

IDBP-95514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WISP3

Protein Name

WNT1 inducible signaling pathway protein 3

Synonyms

CCN6; LIBC; PPAC; PPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000354734

InnateDB Gene

IDBG-95510 (WISP3)

Protein Structure

UniProt Annotation

Function

Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230]: Autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. {ECO:0000269PubMed:10471507}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine. Also expressed in skeletally- derived cells such as synoviocytes and articular cartilage chondrocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005520	insulin-like growth factor binding
GO:0008083	growth factor activity

Biological Process

GO:0001558	regulation of cell growth
GO:0007165	signal transduction
GO:0007267	cell-cell signaling

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR000884 Thrombospondin, type 1 repeat
IPR006207 Cystine knot, C-terminal
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR012395 IGFBP-related, CNN

PFAM

PF00219
PF00090
PF00007

PRINTS

PIRSF

PIRSF036495

SMART

SM00121
SM00209
SM00041

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt