Version 5.4
| Homo sapiens Gene: LAMA4 | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-95551.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | LAMA4 | ||||||||||||||||||
| Gene Name | laminin, alpha 4 | ||||||||||||||||||
| Synonyms | CMD1JJ; LAMA3; LAMA4*-1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000112769 | ||||||||||||||||||
| Encoded Proteins |
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
|
||||||||||||||||||
| Protein Structure |
|
||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011] |
||||||||||||||||||
| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:112108760-112254939 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q21 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
| Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
| Biological Process |
|
||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||
| Orthologs | |||||||||||||||||||
|
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Extracellular matrix organization pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Laminin interactions pathway
|
||||||||||||||||||
| KEGG |
ECM-receptor interaction pathway
Small cell lung cancer pathway
Focal adhesion pathway
Pathways in cancer pathway
Amoebiasis pathway
African trypanosomiasis pathway
Toxoplasmosis pathway
|
||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI |
Beta1 integrin cell surface interactions
Beta3 integrin cell surface interactions
FOXM1 transcription factor network
|
||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q16363 | ||||||||||||||||||
| TrEMBL | E5RFD7 E5RHF3 E5RK79 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 3910 | ||||||||||||||||||
| UniGene | Hs.654572 | ||||||||||||||||||
| RefSeq | NM_001105206 XM_005266983 XM_005266984 XM_006715480 NM_001105207 NM_001105208 NM_001105209 NM_002290 XM_006715481 | ||||||||||||||||||
| HUGO | HGNC:6484 | ||||||||||||||||||
| OMIM | 600133 | ||||||||||||||||||
| CCDS | CCDS43491 CCDS34514 CCDS43492 | ||||||||||||||||||
| HPRD | 02532 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB210027 AL590106 BC004241 BT006690 S78569 X70904 X76939 X91171 Y14240 Z99289 | ||||||||||||||||||
| GenPept | AAB34635 AAH04241 AAP35336 BAE06109 CAA50261 CAA54258 CAA62596 CAA74636 CAI12948 CAI12949 CAI12950 CAI42325 | ||||||||||||||||||
| RNA Seq Atlas | 3910 | ||||||||||||||||||