InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMA4

Summary

InnateDB Protein

IDBP-95555.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMA4

Protein Name

laminin, alpha 4

Synonyms

CMD1JJ; LAMA3; LAMA4*-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000374114

InnateDB Gene

IDBG-95551 (LAMA4)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Disease Associations

Cardiomyopathy, dilated 1JJ (CMD1JJ) [MIM:615235]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269PubMed:17646580}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007172	signal complex assembly
GO:0030155	regulation of cell adhesion
GO:0030198	extracellular matrix organization
GO:0030334	regulation of cell migration
GO:0045995	regulation of embryonic development

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005606	laminin-1 complex
GO:0005925	focal adhesion
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR002049 EGF-like, laminin
IPR005189 Focal adhesion kinase, targeting (FAT) domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009254 Laminin I
IPR010307 Laminin domain II

PFAM