Version 5.4
Homo sapiens Gene: TBL3
Summary
InnateDB Gene IDBG-9565.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBL3
Gene Name transducin (beta)-like 3
Synonyms SAZD; UTP13
Species Homo sapiens
Ensembl Gene ENSG00000183751
Encoded Proteins
IDBP-9567
transducin (beta)-like 3
IDBP-747765
IDBP-753715
IDBP-811340
transducin (beta)-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1972037-1982933
Strand Forward strand
Band p13.3
Transcripts
ENST00000332704 ENSP00000331815
ENST00000568546 ENSP00000454836
ENST00000569792
ENST00000564171
ENST00000569628
ENST00000567615
ENST00000561907 ENSP00000454735
ENST00000615855 ENSP00000481995
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006364 rRNA processing
GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0032040 small-subunit processome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040688
View Gene Order
ENSBTAG00000020366
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10607
UniGene
RefSeq NM_006453
HUGO HGNC:11587
OMIM 605915
CCDS CCDS10453
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 10607

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca