Version 5.4
Homo sapiens Gene: HSF2
Summary
InnateDB Gene IDBG-95987.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSF2
Gene Name heat shock transcription factor 2
Synonyms HSF 2; HSTF 2
Species Homo sapiens
Ensembl Gene ENSG00000025156
Encoded Proteins
IDBP-95989
heat shock transcription factor 2
IDBP-386520
heat shock transcription factor 2
IDBP-813507
heat shock transcription factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:122399546-122433119
Strand Forward strand
Band q22.31
Transcripts
ENST00000368455 ENSP00000357440
ENST00000452194 ENSP00000400380
ENST00000465214 ENSP00000477405
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006950 response to stress
GO:0007283 spermatogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019878
View Gene Order
ENSBTAG00000012946
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt Q03933
TrEMBL V9GZ44
UniProt Splice Variant
Entrez Gene 3298
UniGene Hs.158195 Hs.613261 Hs.674777
RefSeq NM_001135564 NM_004506
HUGO HGNC:5225
OMIM 140581
CCDS CCDS47470 CCDS5124
HPRD
IMGT
EMBL AK294624 AK316377 AL121954 BC112323 BC121050 BC121051 BC128420 CH471051 DQ492684 M65217 Z99129
GenPept AAA36017 AAI12324 AAI21051 AAI21052 AAI28421 ABF47087 BAG57805 BAH14748 CAC14262 CAI20560 EAW48176
RNA Seq Atlas 3298

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca